Mathematical Models Of Energy Homeostasis

To tackle diabetes and obesity, clinicians are now turning to mechanism-based mathematical models to reach quantitative diagnoses of insulin resistance, glucose intolerance and obesity, and to predict the likely outcomes of therapeutic interventions.


A massive range of such models is available, which renders a judicious choice difficult. To better inform this choice, we here present the most important models published to date in a uniform format, discussing similarities and differences in terms of the decisions faced by modellers.


We review models for glucostasis, based on the glucose-insulin feedback control loop, and consider extensions to long-term energy balance, dislipidemia and obesity.


Journal of the Royal Society Interface


Journal of the Royal Society Interface is the Society's cross-disciplinary publication promoting research at the interface between the physical and life sciences. It offers rapidity, visibility and high-quality peer review and is ranked fifth in JCR's multidisciplinary category.


Journal of the Royal Society Interface